Endothelial microvesicles in hypoxic hypoxia diseases
نویسندگان
چکیده
منابع مشابه
Effects of Endothelial Progenitor Cell-Derived Microvesicles on Hypoxia/Reoxygenation-Induced Endothelial Dysfunction and Apoptosis
Oxidative stress-induced endothelial dysfunction plays a key role in ischemia/reperfusion injury. Recent evidence indicates that endothelial progenitor cell-derived microvesicles (EPC-MVs) can promote angiogenesis of endothelial cells (ECs). Here, we investigated the potential effects of EPC-MVs on hypoxia/reoxygenation (H/R) injury in human brain microvascular ECs (hb-ECs). MVs were prepared f...
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Microvesicles (MVs) circulating in the blood are small vesicles (100-1,000 nm in diameter) derived from membrane blebs of cells such as activated platelets, endothelial cells, and leukocytes. A growing body of evidence now supports the concept that platelet-derived microvesicles (PMVs), the most abundant MVs in the circulation, are important regulators of hemostasis, inflammation, and angiogene...
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Acute hypoxia (9.5% O2) increased the heart rate (HR) in hypoxia (12% O2 for 2 months)-acclimated (HX) rats, while it decreased HR in unacclimated (CT) rats. After treatment with propranolol, acute hypoxia decreased HR to the same extent in CT and HX rats. After treatment with atropine, acute hypoxia increased HR in HX rats but not in CT rats. The hypoxia-induced tachycardia in HX rats may be m...
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The purpose of this study was to investigate the potential responses of the cardiovascular system and regional blood flow to hypoxic hypoxia (BB) and to carbon monoxide (CO)-induced hypoxia (COH). Ten anesthetized cats were studied under two nonnoxic (control: CONT) and two hypoxic conditions. Four types of radioactive micro spheres were used to measure regional blood flow during CONT an...
متن کاملMicrovesicles as cell-cell messengers in cardiovascular diseases.
Cell-cell communication has proven to be even more complex than previously thought since the discovery that extracellular vesicles serve as containers of biological information on various pathophysiological settings. Extracellular vesicles are classified into exosomes, microvesicles/microparticles, or apoptotic bodies, originating from different subcellular compartments. The cellular machinery ...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2018
ISSN: 1582-1838
DOI: 10.1111/jcmm.13671